Monthly Archives: May 2006

ASCO Audio Journal of Oncology – June 1st, 2006 – In the company of Gordon McVie

Bevacizumab: New Option for Breast Cancer

robin zon ASCO Audio Journal of Oncology   June 1st, 2006   In the company of Gordon McVie
REFERENCE: 5th European Breast Cancer Conference, Nice, 21st – 25th March 2006
Robin Zon, Michiana Hematology Oncology, South Bend, Indiana
Bevacizumab could be a new treatment option in metastatic breast cancer, according to a study reported at the 5th European Breast Cancer conference in Nice. Derek Thorne spoke to Robin Zon of Michiana Hematology Oncology, in South Bend Indiana, about the study findings.

Radiation for Young Patients with Prostate Cancer?

andre konski ASCO Audio Journal of Oncology   June 1st, 2006   In the company of Gordon McVie
REFERENCE: Cancer, 2006, May 8
André Konski, Fox Chase Cancer Center, Philadelphia
Does age matter when selecting a treatment for patients with early stage prostate cancer? A study reported in the journal Cancer suggests it may not. André Konski told Derek Thorne about a retrospective study carried out at the Fox Chase Cancer Center in Philadelphia.

Better Combine Chemotherapy with Radiation for Hodgkins’ Disease

bridget koontz ASCO Audio Journal of Oncology   June 1st, 2006   In the company of Gordon McVie
REFERENCE: Journal of Clinical Oncology 2006; 24:605
Bridget Koontz, Duke University Medical Center, Durham
In early stage Hodgkin’s Disease many doctors are now using combined modality therapy, involving chemotherapy and a lower dose of radiation. Bus is it any safer than radiation alone? A retrospective study from Duke University Medical Center suggests that it is. Derek Thorne got the details from Bridget Koontz.

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Audio Journal of Infectious Disease – Vaccine to Save Marburg Virus Infected Patients Lives?

tom geisbert Audio Journal of Infectious Disease   Vaccine to Save Marburg Virus Infected Patients Lives?
Thomas Geisbert, US Army Medical Research, Institute of Infectious Diseases, Fort Detrick
REFERENCE: Lancet 2006;367:1399 April 29th, 2006-05-26
A vaccine developed against the Marburg virus has now been reported in the Lancet to have kept monkeys alive when used after they’ve been exposed to the infection. Thomas Geisbert and his colleagues at the US Army Medical Research Institute in Detrick, Maryland, have modified vesicular stomatitis virus for use as a Marburg vaccine. It has already worked in prophylaxis, and now the vaccine has also been found to be effective as a treatment for existing infection. Dr Geisbert talked with Peter Goodwin about his findings.

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Audio Journal of Cardiovascular Medicine: June 2006 – In the company of Michael Petch

michael petch Audio Journal of Cardiovascular Medicine: June 2006   In the company of Michael Petch
Annual Meeting of the American College of Cardiology March 11-14, 2006, Atlanta: Single Agent Bivalirudin Better for Acute Coronary Syndromes; Ultrafiltration vs. Diuretics in Heart Failure; Salt Substitute Lowers Blood Pressure Among High Risk Individuals in China
Michael Petch, Papworth Hospital, Cambridge, UK
REFERENCE: American College of Cardiology Annual Scientific Session March 11-14, 2006, Atlanta
Michael Petch joins Derek Thorne to talk about some more of the news from the 2006 meeting of the ACC in Atlanta. Including:
- Do the results from the ACUITY study support the use of bivalirudin in all types of acute coronary syndrome? We hear from Gregg Stone, from Columbia University, New York, and Michael Lincoff, from the Cleveland Clinic, Ohio
- Ultrafiltration could be an alternative to diuretics in patients with acute decompensated heart failure, according to Maria Rosa Costanzo from the Edward Hospital for Heart Failure in Naperville
- Bruce Neal, of Sydney University, explains how a salt substitute lowered blood pressure in a group of high risk individuals in China

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Audio Journal of Cardiovascular Medicine: May 2006 – In the company of James Tcheng

james tcheng Audio Journal of Cardiovascular Medicine: May 2006   In the company of James Tcheng
Annual Meeting of the American College of Cardiology March 11-14, 2006, Atlanta: Atheroma Reversal, Statins for Acute Coronary Syndromes, Targeting Dual Antiplatelet Therapy, Clopidogrel and Drug Eluting Stents, Catheter Ablation for Atrial Fibrillation
James Tcheng, Duke University, Durham, NC
REFERENCE: American College of Cardiology Annual Scientific Session March 11-14, 2006, Atlanta
The 2006 meeting of the ACC in Atlanta heard from Steven Nissen of the Cleveland Clinic, Ohio how atheroma was observed to significantly regress among patients treated with a statin in the ASTEROID study, and from Anthony Bavry – also of the Clinic – on how early aggressive use of statins helped patients with acute coronary syndromes. Peter Goodwin discussed these findings with James Tcheng who also talks about the CHARISMA trial of dual anti-platelet therapy reported to the ACC by the Cleveland Clinic’s Deepak Bhatt, the BASKET study of late stent thrombosis in drug eluting stents presented in Atlanta by Matthias Pfisterer from the University of Basel, and results of Carlo Pappone from San Raffaele University, Milan, on radio frequency ablation for paroxysmal atrial fibrillation.

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Audio Journal of Medicine – Folate Supplements May Increase Twinning Among Patients Treated with In Vitro Fertilisation

paul haggarty Audio Journal of Medicine   Folate Supplements May Increase Twinning Among Patients Treated with In Vitro Fertilisation
Paul Haggarty, Aberdeen University
REFERENCE: Lancet 2006;367:1513
Folic acid may increase the chance of a twin birth for women undergoing in-vitro fertilisation, according to a recent study published in the Lancet. This finding could present IVF practitioners with something of a dilemma, because on the one hand, twin births are associated with a higher risk of complications for mother and babies; but on the other, folate is an important supplement for women trying to conceive, because it reduces the incidence of neural tube defects such as spina bifida. Paul Haggarty from Aberdeen University told Derek Thorne more about the investigation.

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ASCO Audio Journal of Oncology – May 15th, 2006

Myeloablative Radioimmunotherapy Eases Autologous Stem Cell Transplantations in Patients Age 60 years or Older With Relapsed or Refractory B-Cell Lymphoma

ajay gopal ASCO Audio Journal of Oncology   May 15th, 2006
ABSTRACT: 2005 American Society of Hematology Meeting, Atlanta, Abstract 487
Ajay Gopal, Fred Hutchinson Cancer Research Center, Seattle
Radioimmunotherapy at myeloablative doses may hold the key to treating patients with lymphoma over the age of 60 who would otherwise be denied transplants on grounds of the treatment being too harsh for their age.

New Targeted Therapy for Older Patients With Advanced Acute Myeloid Leukemia

john pagel ASCO Audio Journal of Oncology   May 15th, 2006
REFERENCE: 2005 American Society of Hematology Meeting, Atlanta, Abstract 397
John Pagel, University of Washington, Seattle
Reduced intensity conditioning, sometimes called “mini transplants” offer an option which could safely be used to treat older patients with multiple myeloma.

Phase III Study of Lenalidomide Plus Dexamethasone Versus Dexamethasone Alone in Multiple Myeloma

meletios dimopoulos ASCO Audio Journal of Oncology   May 15th, 2006
REFERENCE: 2005 American Society of Hematology Meeting, Atlanta, Abstract 6
Meletios Dimopoulos, University of Athens, Greece
58% of patients with heavily pre-treated multiple myeloma responded to a combination of the thalidomide analog lenalidomide combined with the standard drug dexamethazone, as compared with only 22% treated with dexamethazone alone. The study of 700 patients found better response rates and time to progression in the lenalidomide-treated group.

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Audio Journal of General Medicine – Antibiotic Benefit in Asthma Exacerbations

sebastian johnston Audio Journal of General Medicine   Antibiotic Benefit in Asthma Exacerbations
Sebastian L. Johnston, Imperial College, London
REFERENCE: N Engl J Med 2006;354:1589
Despite the guidelines recommendation that antibiotics should not normally be used when treating asthma exacerbations, a study published in the New England Journal of Medicine has now shown a benefit. A controlled study with 278 adult patients showed a reduction of asthma symptoms when the ketolide telithromycin was used as compared with placebo. Investigator Sebastian Johnston told Peter Goodwin that more research needs to be done before changing practice.

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ASCO Audio Journal of Oncology – May 1st, 2006 – In the company of Gordon McVie

Tamoxifen After Chemotherapy Protects Premenopausal Patients with Breast Cancer

gordon mcvie ASCO Audio Journal of Oncology   May 1st, 2006   In the company of Gordon McVie
ABSTRACT: J Clin Oncol 24:1322, 2006
Gordon McVie, European Institute of Oncology, Milan
The use of tamoxifen after chemotherapy for premenopausal patients with breast cancer has been shown to almost double disease-free survival among estrogen receptor positive patients, with the greatest benefits among younger patients. These findings emerge from a publication in the Journal of Clinical Oncology by the International Breast Cancer Study group, led by Marco Colleoni of Milan. Gordon McVie from the European Institute of Oncology comments.

Gene Expression Blood Test for Earlier Breast Cancer Detection?

anne lise borresen dale ASCO Audio Journal of Oncology   May 1st, 2006   In the company of Gordon McVie
REFERENCE: 2006 American Association for Cancer Research Annual Meeting, April 1-5, Washington, DC, Abstract 125
Anne-Lise Børresen-Dale, Norwegian Radium Hospital, Oslo
A Norwegian group has identified genes that discriminate breast cancer from non-breast cancer tissues and used them in a blood test for breast cancer and reported high specificity and sensitivity at the 2006 American Association for Cancer Research Annual Meeting in Washington, DC. Anne-Lise Børresen-Dale discussed her results with Karen Regester.

Blood Test of Gene Methylation Detects Early Colorectal Cancer

catherine lofton day ASCO Audio Journal of Oncology   May 1st, 2006   In the company of Gordon McVie
REFERENCE: 2006 American Association for Cancer Research Annual Meeting, April1-5, Washington, DC, Abstract LB-224
Catherine E. Lofton-Day, Epigenomics Inc., Seattle
A new blood test for colorectal cancer that looks for methylation of the septin 9 gene has been found to be more sensitive and specific than fecal occult blood when tested on samples from colonoscopy-defined individuals with colorectal cancer, as compared to those without the disease. Catherine Lofton-Day from Epigenomics Inc. of Seattle talked about the test during the 2006 American Association for Cancer Research Annual Meeting in Washington, DC.

Airway Gene Signatures Detect Early Lung Cancer

avrum spira ASCO Audio Journal of Oncology   May 1st, 2006   In the company of Gordon McVie
REFERENCE: 2006 American Association for Cancer Research Annual Meeting, April1-5, Washington, DC, Abstract 2420
Avrum Spira, Boston University
Airway gene signatures may be the ideal test to be added to bronchoscopy for diagnosing early lung cancer according to findings presented to the 2006 American Association for Cancer Research Annual Meeting in Washington, DC. Avrum Spira from Boston University said that where bronchoscopy is weakest, gene profiling is strongest: picking up 90 % of early cancers, as compared with only 30 % from bronchoscopy alone.

Nicotine Can Inhibit Lung Cancer Chemotherapy

REFERENCE: 2006 American Association for Cancer Research Annual Meeting,April 1-5, 2006, Washington, DC, Abstract 787
Piyali Dasgupta, H. Lee Moffitt Cancer Center, Tampa
Smoking has been observed to reduce the effectiveness of chemotherapy for non-small cell lung cancer, and according to findings presented to the 2006 American Association for Cancer Research Annual Meeting in Washington, DC, it is the nicotine in cigarette smoke that is mainly responsible for the effect, and not necessarily the hundreds of other toxic components of the smoke. Pivali Dasgupta from the Moffitt Cancer Center in Tampa told Audio Medica about her findings.

Intraperitoneal Therapy and Survival in Ovarian Cancer

gordon mcvie ASCO Audio Journal of Oncology   May 1st, 2006   In the company of Gordon McVie
ABSTRACT:J Clin Oncol 24:1322, 2006, N Engl J Med 354:3, 2006
Gordon McVie, European Institute of Oncology, Milan
Intraperitoneal therapy for ovarian cancer has achieved successes recently with improvements in median survival among patients receiving a number of different regimens intraperitoneally as compared with intravenously, and a new study from Nijmegen on the use of monoclonal antibody known to target cells has now been published in the Journal of Clinical Oncology. Gordon McVie from the European Institute of Oncology comments on these reports, and about the potential for improving ovarian cancer survival based on the new therapies recently investigated.

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