Daniel Diekema, University of Iowa, Iowa City
A large, global survey of candida distribution and drug susceptibility reported at the ICAAC found that fluconazole resistance among candida glabrata appears to be increasing.
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Louis Bourgeois, Johns Hopkins University, Baltimore
Among the various experiences when visiting a developing country: there’s amazement at the sounds and the colour; delight at the warmth of the people and the climate; but also, unfortunately, travelers’ diarrhea. But the main causal bacterium, enterotoxigenic E. coli – or ETEC – is also responsible for a large amount of morbidity and mortality among children who live in the developing world. So, interest was stoked at ICAAC by the possibility of an oral killed vaccine for travellers’ diarrhea which has now been used in a double blind, randomised study involving 1400 people.
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Roy Gulick, Weill Cornell Medical College, New York
Although the logic in antiretroviral HIV therapy has, for some years, been that two drugs are better than one; and three are better than two, this has not continued. A late breaking study involving 700 patients presented on this at ICAAC found that four drugs are not better than three, but that a worrying relationship exists between race and time to virologic failure.
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Timothy Wilkin, Weill Cornell Medical College, New York
A protease inhibitor, currently known as TMC114 has been tested in the POWER II study among some 300 patients who had failed multiple regimens. Six month data have now yielded dose and toxicity findings and some preliminary recommendations for therapeutic use.
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Thomas Cherpes, University of Pittsburgh School of Medicine
One thought provoking study at ICAAC explored the possible link between pelvic inflammatory disease, or PID, and herpes simplex virus 2. It reported an association of the virus with endometritis, fallopian tube blockage, and other complications in 700 women who had, or who were at risk of, a lower genital tract infection.
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