CHRIS CURTIS, London School of Hygiene and Tropical Medicine
The current method of distributing insecticidal nets for malaria isn’t working well enough. Chris Curtis explains what needs to be done.
Jean Jannin
Renewed Battle Against Chagas Disease
JEAN JANNIN, World Health Organisation
MICHAEL MILES, London School of Hygiene and Tropical Medicine Jean Jannin of the WHO discusses the organisation’s new push to eliminate Chagas Disease; and Michael Mills explains how London School research will contribute.
Harold Margolis
Quiet Progress for the Dengue Vaccine
REFERENCE: www.pdvi.org HAROLD MARGOLIS, Pediatric Dengue Vaccine Initiative, Seoul Harold Margolis, director of the Pediatric Dengue Vaccine Initiative, describes current progress in the development of a vaccine for dengue fever.
REFERENCE: ABSTRACT N Engl J Med 2007; 357: 28-381 STUART POCOCK, London School of Hygiene and Tropical Medicine
Reassuring findings about the safety of the anti-diabetic drug rosiglitazone have been published in the New England Journal of Medicine following an interim analysis of the Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD) study. This latest publication follows a meta-analysis in June 2007 by Nissen and Wolski which raised doubt about the safety of the drug. Nicola Solomon spoke with the RECORD trial’s statistician, Stuart Pocock, to get the latest data from this largest study specifically designed to look at cardiovascular outcomes.
MARTIN MCKEE, London School of Hygiene and Tropical Medicine Martin McKee on the smoking ban – and how the tobacco industry is now looking to promote oral tobacco. Is it an effort to keep people addicted?
Virginia Berridge
Health Politics Must Involve History
REFERENCE: The Guardian, 20th June VIRGINIA BERRIDGE, London School of Hygiene and Tropical Medicine Virginia Berridge on how the past holds important lessons for public health in the present.
Martin McKee
Alcohol Consumption in Russian Men
REFERENCE: The Lancet 2007; 369:2001-2009 MARTIN MCKEE, London School of Hygiene and Tropical Medicine Martin McKee also discusses the new study on alcohol and mortality in working-age Russian men, and evidence that non-beverage alcohol is a major cause of early death.
MISHAL KHAN, London School of Hygiene and Tropical Medicine
REFERENCE: The Lancet 2007; 369:1955-1960
Giving comprehensive instructions to women before they produce a sputum sample can make tuberculosis detection more effective – that’s the conclusion of a study published in the Lancet. A team from the UK and Pakistan carried out a large randomised trial in both men and women, and Derek Thorne got the details from Mishal Khan, of the London School of Hygiene and Tropical Medicine.
JAIME MIRANDA, London School of Hygiene and Tropical Medicine, Peru
An antifibrinolytic agent, tranexamic acid (commonly used to reduce bleeding during surgery) is being investigated as first-aid to cut mortality and the need for blood transfusion immediately after trauma or injury. The CRASH trial, still in its early phases in a worldwide adult population, aims to bring particular benefit to developing countries, many of which are blighted by trauma with few measures, if any, having been available up to now to reduce the death toll. In Lima, Peru, Jaime Miranda discussed his group’s ongoing investigation with Peter Goodwin.
JAIME MIRANDA, London School of Hygiene and Tropical Medicine, Peru
The consequences of migration from rural to urban areas in Peru has provided an opportunity for studying the impact of a radically altered lifestyle and diet upon health. Jaime Miranda is investigating the disease patterns among migrants from the Andes Mountains and the Amazon Jungle regions of Peru in the capital, Lima. He discussed his group’s investigation with Peter Goodwin.
PHILIPPE MAYAUD, London School of Hygiene and Tropical Medicine
REFERENCE: N Engl J Med 2007; 356: 790-9
In patients who are infected with both HIV and herpes simplex type 2 the activity of the AIDS virus may be diminished by therapy with one of the established anti-herpes drugs, according to the findings of a study published in the New England Journal of Medicine by authors in France, England and Burkina Faso. Philippe Mayaud talked about his results with Peter Goodwin in which HIV concentrations in the blood and vagina of patients co-infected with both herpes and HIV were found to be reduced by continuous treatment with the anti-herpes agent valacyclovir.
PAT DOYLE, London School of Hygiene and Tropical Medicine
REFERENCE: BJOG 2007 114:170
Underweight women were found to be at increased risk of miscarriage in a study published in the British Journal of Obstetrics and Gynaecology. A team from the London School of Hygiene and Tropical Medicine conducted a survey by questionnaire of 6 000 women among whom 600 had a first trimester miscarriage. Using a “case-control” method of comparison it emerged that women with a body mass index below 18.5 had a 70 per cent increase in their risk of miscarriage. Peter Goodwin heard more about the study from Pat Doyle of the London School of Hygiene and Tropical Medicine.
CHARLOTTE WATTS, London School of Hygiene and Tropical Medicine
REFERENCE: Lancet 2006; 368: 1973-83
A large and groundbreaking study has shown that microfinance, combined with a gender and HIV training scheme, can help reduce domestic violence among poor women living in rural South Africa. Charlotte Watts of the London School of Hygiene and Tropical Medicine told Derek Thorne about the IMAGE study.
REFERENCE: The Lancet (online 1st November 2006) Anna Glasier, University of Edinburgh,
Kaye Wellings, London School of Hygiene and Tropical Medicine
John Cleland, London School of Hygiene and Tropical Medicine
Joy Phumaphi, Assistant Director General, World Health Organization
Sexual and reproductive health has been neglected and needs to be put back on the global health agenda, according to a series of articles published in The Lancet. Together with the London School of Hygiene and Tropical Medicine, the Audio Journal of Global Health Issues investigates the world-wide challenge facing healthcare professionals over sexually transmitted diseases, unsafe abortions, contraception and complications in pregnancy. At a briefing hosted by Lancet Editor Richard Horton, Derek Thorne spoke with Anna Glasier about why these issues have been neglected; Kaye Wellings revealed fascinating and unexpected findings on worldwide sexual behaviour; John Cleland explained why family planning has a crucial rôle to play; and Joy Phumaphi, talked about The World Health Organizations’s commitment to improving reproductive health.
Andy Haines, London School of Hygiene and Tropical Medicine
In Sub-Saharan Africa, antiretroviral therapy for HIV/AIDS is becoming more available and more affordable. However, coverage is still far from complete. Andy Haines, director of the London School of Hygiene and Tropical Medicine, recently attended a workshop in Uganda which focussed on antiretroviral delivery. He spoke to Derek Thorne about the current initiatives and the challenges that lie ahead.
Richard Coker, London School of Hygiene and Tropical Medicine REFERENCE: Lancet online: 20th April, 2006-04-20
The preparedness of Europe for the possible onslaught of avian flu is assessed in a publication in the Lancet comparing the activities of 29
European countries. Lead author Richard Coker at the London School of Hygiene and Tropical Medicine told Audio Medica’s Peter Goodwin how these plans will affect individual doctors and medical professionals.