Medicine

Tumour Necrosis Factor Up-regulation: Key to Severe Asthma?

February 23, 2006 ⋅ Post a comment
Ian D Pavord

Ian D Pavord, Glenfield Hospital, University of Leicester
Abstract N Engl J Med 2006 ; 354:697
A key underlying factor in severe asthma may have been uncovered according to findings now published in the New England Journal of Medicine. Mike Berry, Ian Pavord and their group at Leicester University’s Glenfield Hospital in the United Kingdom have found that TNF up-regulation seems to be an important, and perhaps crucial, factor underlying severe cases of the disease. The study provides hope that treatments modulating tumour necrosis factor alpha could help combat refractory asthma in the future.

Similar Interviews

  • Audio Journal of General Medicine - Antibiotic Benefit in Asthma Exacerbations

    • Sebastian L. Johnston, Imperial College, London REFERENCE: N Engl J Med 2006;354:1589 Despite the guidelines recommendation that antibiotics should not normally be

  • Rosiglitazone for Patients with Diabetes: Cardiovascular Outcomes Trial Findings

    • Stuart Pocock REFERENCE: ABSTRACT N Engl J Med 2007; 357: 28-381 STUART POCOCK, London School of

  • Audio Journal of Oncology in Advance - April 15th, 2007 - Bisphosphonates Recommended for Lung Cancer Bone Metastases

    • PETER HARPER, Guy’s Hospital, London REFERENCE: “Management of Tumour and Treatment Related Symptoms” section, Perspectives in Lung Cancer, Seville Bisphosphonates may be

    Post a comment

    Health For All 30 Years After Alma Ata? Mental Health And War»
    AliaIbrahim Zai, Egbert Sondorp, Gill Walt, Lucy Gilson, Ravi Narayan, Richard Horton, Vikram Patel, Willem Van De Put
    Two important symposia have been held in London to discuss healthcare issues posing significant dilemmas to world leaders in the 21st Century. "The Future of Primary Health Care" was attended by public health experts from around the Globe to assess the best options for improving primary health care in the future. It was held on the 30th anniversary of the Alma Ata Declaration made in 1977 which was intended as a blueprint for health provision and identified primary health care as the means through which the global goal of "Health for All" could be achieved. The second meeting, on "Mental Health in Fragile States", was held to raise the profile of mental health care in zones where conflict has taken place or is still happening. Analyses of the key issues and how to deal with them effectively were discussed by top experts from the London School of Hygiene and Tropical Medicine and associated organisations. Peter Goodwin attended both meetings and talked with some of the key speakers.
    LSHTM Audio News: British Association Special Edition»
    Astrid Fletcher, Jo Lines, Sari Kovats, Colin Sutherland, Michel Coleman
    Peter Goodwin hears from London School of Hygiene and Tropical Medicine experts speaking at the annual science festival of the British Association for the Advancement of Science held in Liverpool, September 6-10, 2008, and from recent scientific publications on: the health impact of global warming, a tropical virus reaching temperate zones, inequalities in cancer outcomes, how eating oily fish can save your eyesight, and free internet publishing scientific journals.
    Subscribe to Audio Medica Podcast