Volume 16 Number 6 (March 15th, 2008) reporting from:
4th European Congress on Hematologic Malignancies (February 22-24, 2008, Paris)
American Society of Hematology Annual Meeting (December 8-11, 2007 Atlanta)
Chemotherapy Foundation Symposium, November 7-10, 2007, New York
David Maloney
Nonmyeloablative Alogeneic Transplants Ready for Prime-Time in Follicular Lymphoma?
David Maloney, Fred Hutchinson Cancer Research Center, Seattle
Allogeneic transplantation is now a good option for treating some patient groups with follicular lymphoma. David Maloney explained to Peter Goodwin in Paris how his group has harnessed graft-versus-tumor effect by using nonmyeloablative conditioning without causing unacceptable risks of graft-versus-host disease.
Carolyn Krasner
Trabectedin Activity in Platinum-Sensitive Relapsed Ovarian Cancer
Carolyn Krasner, Massachusetts General Hospital, Boston
Could trabectedin, which has a novel mechanism of action, be a useful agent for patients with relapsed ovarian cancer? Derek Thorne discussed this question in New York with Carolyn Krasner, whose data show the greatest benefit in patients who are sensitive to platinum agents.
Kirk Schultz Armand Keating
High-Dose Chemotherapy Plus Imatinib Benefits Pediatric Acute Lymphoblastic Leukemia
Kirk Schultz, British Columbia Children’s Hospital, Vancouver COMMENT: Armand Keating, Princess Margaret Hospital, Toronto
For children with acute lymphoblastic leukemia, high-dose chemotherapy combined with imatinib appears to show a survival benefit. Sarah Maxwell spoke with study author Kirk Schultz at the ASH meeting in Atlanta, and Armand Keating provided comment.
John Gribben
Chronic Lymphocytic Leukemia: New Options After Fludarabine Failure
John Gribben, Bartholemews Hospital, London
New treatments for chronic lymphocytic leukemia were discussed in Paris by John Gribben. He gave Peter Goodwin his assessment of antibody therapies such as rituximab and alemtuzumab and new drugs such as lenalidomide, and combinations including standard fludarabine therapy.
DAVID JABLONS, University of California, San Francisco
REFERENCE: Keynote Lecture, Perspectives in Lung Cancer Conference, 2-3 March 2007, Seville, Spain
Cell signalling
PETER HARPER, Guy’s Hospital, London
REFERENCE: “Management of Tumour and Treatment Related Symptoms” section, Perspectives in Lung Cancer, Seville
Bisphosphonates may be
IAN SMITH, Royal Marsden Hospital, London
REFERENCE: Lancet 369:29
Confirmation of the life-extending benefits of trastuzumab adjuvant therapy for early breast
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