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Category: AJO

oncology

  • Gender Disparity in Head and Neck Cancer Treatment and Outcomes
    • in AJO · Audio · Oncology
    • — 9 Jun, 2018

    Gender Disparity in Head and Neck Cancer Treatment and Outcomes

    CHICAGO—Women and men were treated differently for the same tumor stages of head and neck cancer (HNC) and had different outcomes in a study with patients surveyed over a fifteen-year period in Santa Clara, California. The findings—using the generalized competing …

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    Lung Cancer
    • in AJO · Audio · Oncology
    • — 8 Jun, 2018

    Pembrolizuab Monotherapy Extended Survival in Advanced Lung Cancer

    CHICAGO, IL—Patients whose non-small cell lung cancers (NSCLC) expressed more than one per cent of the programmed death ligand-1 (PD-L1) tumor proportion score (TPS) lived longer when treated with the anti programmed death 1 (PD-1) antibody pembrolizumab than a control …

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  • Ultrahypofractionated Radiation Just As Effective for Prostate Cancer
    • in AJO · Audio · News · Oncology
    • — 16 May, 2018

    Ultrahypofractionated Radiation Just As Effective for Prostate Cancer

    BARCELONA—Ultrahypofractionated radiation (U-HF) delivered in only seven fractions (each triple the usual dose) in two and a half weeks was just as effective for treating intermediate-risk prostate cancer—with no greater toxicity—as a standard protocol with 39 fractions over eight-weeks in …

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    Interval Breast Lumps signal cancer risk
    • in AJO · Audio · Oncology
    • — 19 Apr, 2018

    Breast Lumps Between Mammography Visits Signal High Risk

    BARCELONA—Women who develop breast symptoms—especially lumps—between regular mammography screening examinations are up to four times more likely to have a diagnosis of breast cancer soon after than women who do not have symptoms according to findings of a massive study …

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  • Ribociclib Aids First-Line Endocrine Therapy in Premenopausal Advanced Breast Cancer
    • in AJO · Audio · Oncology
    • — 18 Apr, 2018

    Ribociclib Aids First-Line Endocrine Therapy in Premenopausal Advanced Breast Cancer

    BARCELONA—More pre-menopausal women who have estrogen receptor (ER) positive advanced breast cancer could be spared chemotherapy—according to latest findings from the MONALEESA-7 double-blind randomized phase 3 trial in which either placebo (PBO) or the cyclin-dependent kinase (CDK) 4/6 inhibitor ribociclib …

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    Reassurance on Ductal Carcinoma in Situ (DCIS) Treatment De-Escalation
    • in AJO · Audio · Oncology
    • — 17 Apr, 2018

    Reassurance on Ductal Carcinoma in Situ (DCIS) Treatment De-Escalation

    BARCELONA—A multicenter nationwide Italian study of patients with ductal carcinoma in situ (DCIS) treated with breast conservative surgery (BCS) and whole breast radiotherapy (RT) has updated risk criteria to help women opt for gentler treatments and avoid toxicities from overtreatment.…

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  • Breast Cancer: Combined Risk Assessment Prompts Treatment De-Escalation
    • in AJO · Audio · Oncology
    • — 16 Apr, 2018

    Breast Cancer: Combined Risk Assessment Prompts Treatment De-Escalation

    BARCELONA—Not only was breast conserving therapy safer than mastectomy for most low-risk patients in the large randomized EORTC 10041/BIG 03-04 MINDACT trial reported at the 2018 European Breast Cancer Conference but also many patients could be advised to avoid chemotherapy …

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    Double Mastectomy: No Survival Gain for BRCA2 Mutation Carriers—AUDIO JOURNAL OF ONCOLOGY
    • in AJO · Audio · Oncology
    • — 30 Mar, 2018

    Double Mastectomy: No Survival Gain for BRCA2 Mutation Carriers—AUDIO JOURNAL OF ONCOLOGY

    BARCELONA—Healthy women with BRCA1 mutations who opted for bilateral prophylactic mastectomy had their lives prolonged in comparison with similar women who did not. But in healthy women with the BRCA2 mutation the procedure did not improve overall survival even though …

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  • Polygenic Risk Scores Could Help Predict Second Primary Breast Cancers—AUDIO JOURNAL OF ONCOLOGY
    • in AJO · Audio · Oncology
    • — 28 Mar, 2018

    Polygenic Risk Scores Could Help Predict Second Primary Breast Cancers—AUDIO JOURNAL OF ONCOLOGY

    BARCELONA—Patients treated for BRCA-associated breast cancers could be given more accurate estimates of the risk for developing second primaries of the contralateral breast by combining polygenic risk scores (PRS) with standard risk factors if study findings reported at the 2018 …

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    Venetoclax Pro-Apoptotic Therapy Benefits Older Patients with Acute Myeloid Leukemia
    • in AJO · Audio · Oncology
    • — 19 Jan, 2018

    Venetoclax Pro-Apoptotic Therapy Benefits Older Patients with Acute Myeloid Leukemia

    ATLANTA—Adding anti-BCL-2 therapy with the small-molecule drug venetoclax (VEN) to standard low-dose cytarabine (LDAC) chemotherapy tripled response rates over historical comparators and extended survival in older patients with acute myeloid leukemia (AML) who were ineligible for intensification of their chemotherapy …

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  • Prostate Genomics—Which Patients Will Die?
    • in AJO · Audio · Oncology
    • — 20 Apr, 2017

    Prostate Genomics—Which Patients Will Die?

    MILAN, Italy—Genomic profiling could help reduce the risk of over-treatment in primary prostate cancer (PC) by identifying patients and healthy individuals whose genes put them at greatest risk of developing dangerous disseminated disease said Norman J Maitland PhD, Professor of …

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    Which High-Risk Prostate Cancers Need Multimodality Treatment?
    • in AJO · Audio · Oncology
    • — 18 Apr, 2017

    Which High-Risk Prostate Cancers Need Multimodality Treatment?

    MILAN, Italy—Patients with node-positive prostate cancer being treated with prostatectomy could derive benefit from early multimodality therapy combining androgen deprivation therapy (ADT) with radiotherapy (RT)—on top of surgery—if they have pathological features indicating high risk, according to findings reported at …

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