LONDON— Researchers have shown that endometrial cancer — and hopefully ovarian cancer too — could potentially be detected much earlier than at present — or even prevented altogether — by looking for ‘silencing’ by DNA methylation of the HAND2 gene: an ‘epigenetic’ process which is not inherited but imposed by the environment to cause cancer. In a study reported in PLoS Medicine (http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001551) using animal models and tissue samples from patients at University College London Hospital data are presented which promise an era of more individualised therapy thanks to a more complete understanding of the full picture of gene control over cancer — which includes a far greater proportion of epigenetic processes than inherited ones. Professor Martin Widschwendter MD, who is UCL Chair in Women’s Cancer and Head of Department, and Consultant Gynaecological Oncology Surgeon at UCL EGA Institute for WomenÂ´s Health, University College London, discusses the clinical implications of the new research for detecting, preventing and treating cancer. Lead study author Ms Allison Jones describes the importance of epigenetic processes in comparison with inherited genetic factors in causing cancer. Dr Daniel Reisell MB, BS, PhD discusses the motivation of patients participating in the research on the HAND2 gene’s role in cancer.
You may also like...
New drug looks very promising in high risk chronic lymphocytic leukaemia 11 Dec, 2012 Lung Cancer Radiation Therapy Increases Heart Disease Mortality 24 Aug, 2016 ASCO Audio Journal of Oncology – September 15th, 2006 14 Sep, 2006 Reassurance on Ductal Carcinoma in Situ (DCIS) Treatment De-Escalation 17 Apr, 2018
- Previous story Chimeric antigen receptor T-cell therapy: high remission rate in relapsed, refractory acute lymphoblastic leukemia
- Next story First effective treatment for “orphan disease’: Anti I/L 6 antibody brings remissions in Multicentric Castleman’s Disease
- COVID-19 Co-Morbidity Risks Quantified from Three Continents SurveyMay 28, 2020
- Ultrahypofractionated Radiation Just As Effective for Prostate CancerMay 16, 2018
- First evidence that genome editing made patients with AIDS more resistant to HIVMarch 8, 2014
- Anticoagulation with warfarin can be beneficial in patients with atrial fibrillation and chronic kidney disease.March 7, 2014
- Prostate cancer: Adult exposure to bisphenol-A linked to prostate cancer riskMarch 6, 2014