LONDON— Researchers have shown that endometrial cancer — and hopefully ovarian cancer too — could potentially be detected much earlier than at present — or even prevented altogether — by looking for ‘silencing’ by DNA methylation of the HAND2 gene: an ‘epigenetic’ process which is not inherited but imposed by the environment to cause cancer. In a study reported in PLoS Medicine (http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001551) using animal models and tissue samples from patients at University College London Hospital data are presented which promise an era of more individualised therapy thanks to a more complete understanding of the full picture of gene control over cancer — which includes a far greater proportion of epigenetic processes than inherited ones. Professor Martin Widschwendter MD, who is UCL Chair in Women’s Cancer and Head of Department, and Consultant Gynaecological Oncology Surgeon at UCL EGA Institute for Women´s Health, University College London, discusses the clinical implications of the new research for detecting, preventing and treating cancer. Lead study author Ms Allison Jones describes the importance of epigenetic processes in comparison with inherited genetic factors in causing cancer. Dr Daniel Reisell MB, BS, PhD discusses the motivation of patients participating in the research on the HAND2 gene’s role in cancer.
You may also like...
Phase-III Randomized ARCON Trial: Comment from Hans Kaanders 12 May, 2015 Esophageal Cancer Prevented By Proton Pump Inhibitor Plus Aspirin 15 Aug, 2018 Stage IV Pancreatic Islet Cell Tumors: Sunitinib Monotherapy Increased Progression Free Survival 28 Jul, 2009 Audio Journal of Oncology in Advance – March 15th, 2008 16 Mar, 2008
- Previous story Chimeric antigen receptor T-cell therapy: high remission rate in relapsed, refractory acute lymphoblastic leukemia
- Next story First effective treatment for “orphan disease’: Anti I/L 6 antibody brings remissions in Multicentric Castleman’s Disease
- Ultrahypofractionated Radiation Just As Effective for Prostate CancerMay 16, 2018
- First evidence that genome editing made patients with AIDS more resistant to HIVMarch 8, 2014
- Anticoagulation with warfarin can be beneficial in patients with atrial fibrillation and chronic kidney disease.March 7, 2014
- Prostate cancer: Adult exposure to bisphenol-A linked to prostate cancer riskMarch 6, 2014
- MMR vaccine’s non-specific effects: adherence to recommended vaccination schedules protects children against non-vaccination-specific infections tooFebruary 28, 2014