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Robert Pirker

Scientific Editors:
George Canellos, Dana-Farber Cancer Institute, Boston
Gordon McVie, European Institute of Oncology, Milan
Pat Price, Christie Hospital, Manchester
Gianni Bonadonna, Istituto Nazionale Tumori, Milan

Sarah Maxwell and Peter Goodwin report on evidence that combining monoclonal antibodies with chemotherapy can extend life among patients with advanced non-small-cell lung cancer. Robert Pirker from the Medical University of Vienna tells Sarah Maxwell about his group’s findings in the FLEX study using the epidermal growth factor receptor (EGF-R) inhibitor cetuximab; Christian Manegold from Heidelberg University, Manheim gives Peter Goodwin data on the vascular endothelial growth factor (VEGF-R) bevacizumab; while Giorgio Scagliotti from Torino University, Nick Thatcher from the Christie Hospital, Manchester and Howard Sandler from the University of Michigan, Ann Arbor discuss the clinical implications of these approaches to using molecular targeting to improve outcomes in advanced non-small-cell lung cancer. Michel Coleman from the London School of Hygiene and Tropical Medicine tells Peter Goodwin about the findings of the CONCORD study looking at international differences between survival rates for breast, prostate and colorectal cancers.

Christian Manegold

Giorgio Scagliotti

Nick Thatcher

Michel Coleman

Brian Greenwood

Brian Greenwood and David Conway tell Peter Goodwin how the incidence of malaria has fallen dramatically in The Gambia following the use of simple interventions such as insecticide-treated bed nets, and resistance-free drugs. The question now being asked is: Can malaria be eradicated? Isobel dos Santos Silva explains how birth-weight affects your risk of developing breast cancer later in life; Astrid Fletcher describes the way anti-oxidants from fruit and vegetables in a normal diet (as reported in the EUREYE study conducted in seven centres in Europe from Bergen in Norway to Alicante in Spain) may be protecting our eyes against macular degeneration and possible blindness caused by strong sunlight.

David Conway

Isobel dos Santos Silva

Astrid Fletcher