
George Canellos

Robert Motzer
Hormone Replacement Therapy: Better Survival With Colorectal Cancer
REFERENCE: J Clin Oncol 24:5680-5686
GEORGE CANELLOS, Dana-Farber Cancer Institute, Boston
Using postmenopausal estrogen replacement before the diagnosis of colorectal cancer was associated with better cancer-specific and overall mortality. This is the finding of a study by Jennifer Chan and colleagues from the Dana-Farber Cancer Institute and Massachusetts General Hospital in Boston. Peter Goodwin talked with George Canellos about the finding and its implications for therapy.
High-Dose Chemotherapy With Stem Cell Rescue: No Benefit as First-Line Therapy in Metastatic Germ Cell Tumors
REFERENCE: J Clin Oncol 25: 247-256
GEORGE CANELLOS, Dana-Farber Cancer Institute, Boston
No advantage has emerged from high-dose chemotherapy as first-line therapy in patients with poor- and intermediate-risk metastatic germ cell tumors. A phase III randomized study comparing high-dose with standard-dose chemotherapy has been published in the Journal of Clinical Oncology by a group led by Robert Motzer of Memorial Sloan-Kettering Cancer Center in New York. George Canellos discusses these findings with Peter Goodwin and puts them into context with other recent related study findings.