Tumour Necrosis Factor Up-regulation: Key to Severe Asthma?

Ian D Pavord, Glenfield Hospital, University of Leicester
Abstract N Engl J Med 2006 ; 354:697
A key underlying factor in severe asthma may have been uncovered according to findings now published in the New England Journal of Medicine. Mike Berry, Ian Pavord and their group at Leicester University’s Glenfield Hospital in the United Kingdom have found that TNF up-regulation seems to be an important, and perhaps crucial, factor underlying severe cases of the disease. The study provides hope that treatments modulating tumour necrosis factor alpha could help combat refractory asthma in the future.
[audio:https://www.audiomedica.com/podcasting/news/ian_d_pavord.mp3]