EDINBURGH, SCOTLAND—A randomized study has reported in the Lancet that in patients with paracetamol overdose, a shorter (12 hour) course of a modified acetyl-cysteine regimen with or without ondansetron pre-treatment induced less vomiting, led to fewer anaphylactoid reactions and reduced the need for interrupting treatment compared to the standard regimen of 20 to 25 hours.
The authors note, however, that the efficacy of the shorter modified regimen still needs to be evaluated.
AUTHOR: Professor Nicholas Bateman N.D. et al.
SOURCE: Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial, The Lancet, Volume 383, Issue 9918, Pages 697 – 704, 22 February 2014.DOI:10.1016/S0140-6736(13)62062-0
LINK: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2813%2962062-0/abstract
National Poisons Information Service, Royal Infirmary of Edinburgh, Edinburgh, UK
Paracetamol Poisoning: 12-hour modified acetylcysteine treatment for paracetamol poisoning reduced side effects associated with standard regimen.
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